欧州硬組織学会ECTS in BUDAPEST 2019
欧州硬組織学会ECTS 2019に 参加しました。
以下はシンポジウムで発表した概要です。
ECTS2019, 11-14 May, Budapest, HUNGARY
Trichloroethylene-related Compound S-(1, 2-dichlorovinyl)-L-cysteine Localized on Mouse Cartilage
Hiromi Hagiwara, Nobuaki Shirai, Norikazu Komoriya, Hiroki Tomisawa
Department of Biomedical Engineering, Toin University of Yokohama, Yokohama, Japan
Tsukuba Labs., Nemoto Science Co. Ltd., Ibaraki, Japan
Abstract
Trichloroethylene (TCE) is generally used as synthetic material for alternative fluorocarbon or metal-degreasing agent. TCE is metabolized into S-(1, 2-dichlorovinyl)-L-cysteine (DCVC) in the body and DCVC is well known to cause renal-cellular injury after metabolic activation by cysteine conjugate β-lyase. We performed the in vivo disposition of [35S] DCVC in mice after intraperitoneal administration at a dose of 30 mg/kg (6 mg/2.42 MBq/ml). DCVC was well absorbed rapidly, distributed highly in the kidneys and moderately in the pancreas, liver, and bone. Furthermore, we revealed by whole-body autoradiography that DCVC and its related substances were localized on the femoral epiphysis, vertebral endplates, and tracheal cartilage in mouse.
Keywords DCVC・Autoradiography・Cartilage・Mouse
 |
|