世界骨粗鬆症会議 IOF in Singapore 2016

seville title image IOFガイドブック


2016 アジア・環太平洋骨粗鬆症学会 November 4 - 6に 参加しました。

以下はシンポジウムで発表した概要です。


Chalcone 4-Hydroxyderricin Inhibits Osteoclast Formation and Accelerates Osteoblast Differentiation


Hiromi Hagiwara, Kyoko Nakata, Kaoru Yoshida
Faculty of Biomedical Engineering, Toin University of Yokohama, 1614 Kurogane-cho, Aoba-ku, Yokohama 225-8503, Japan

Abstract
4-Hydroxyderricin (4-HD) is a major polyphenol of Angelica keiskei (Ashitaba), exhibiting antiallergic, antidiabetic, antioxidant, and antitumor effects. The present study was designed to evaluate the effects of 4-HD on bone formation and maintenance by using cultured osteoclasts and osteoblasts. 4-HD did not affect cell proliferation of stromal ST2 cells and preosteoblast MC3T3-E1 cells at concentrations of 1 μM to 10 μM. This compound inhibited the formation of multinucleated osteoclasts from mouse splenic cells, and we identified a molecular pathway of osteoclast differentiation mediated by 4-HD, which led to inhibition of the expression of receptor activator of nuclear factor-κB ligand and macrophage-colony stimulating factor in ST2 cells. By contrast, 4-HD enhanced indices of osteoblast differentiation, such as alkaline phosphatase activity and calcium deposition by osteoblastic MC3T3-E1 cells, at concentrations of 1 μM to 10 μM. Our findings indicate that 4-HD may have critical effects on bone metabolism.