発表論文

2019年

4-Hydroxyderricin inhibits osteoclast formation and accelerates osteoblast differentiation.
Hagiwara H, Nakata K, Miyazaki H, Maehashi S, Komiyama Y, Aida R, Yoshida S, Kokubu D, Hagiwara K, Yoshida K.
Cytotechnology. 2019 Feb;71(1):15-22.


2016年

Abnormal Spermatogenesis and Male Infertility in Testicular Zinc Finger Protein ZFP318-knockout Mouse.
Masamichi Ishizuka, Eri Ohtsuka, Atsuto Inoue, Mirei Odaka, Hirotaka Ohshima, Norihisa Tamura, Kaoru Yoshida, Norihisa Sako, Katsutosi Sasaki, Tadashi Baba, Shin-ichi Kashiwabara, Masaru Okabe, Jyunko Noguchi, and Hiromi Hagiwara
Development Growth & Differentiation, 58, 600-608 (2016)


2015年

Carnosic Acid Inhibits the Formation of Osteoclasts through Attenuation of Expression of RANKL.
Hiromi Hagiwara, Roshan Basnet, Sundari I. Wiyasihati, Kyoko Nakata, Keitaro Hagiwara,Hitoshi Miyazaki, and Kaoru Yoshida
PharmaNutriton, 3(1), 1-6 (2015) Doi: 10.1016/j.phanu.2014.11.003


Apigenin Inhibits Osteoblastogenesis and Osteoclastogenesis and Prevents Bone Loss in Ovariectomized Mice.
Tadashi Goto, Keitaro Hagiwara, Nobuyuki Shirai, Kaoru Yoshida, and Hiromi Hagiwara
TCytotechnology, Published online Doi/10.1007/s10616-014-9694-3 (2014)


2014年

Zinc-finger Protein ZFP318 Is Essential for Expression of IgD, the Alternatively Spliced Igh Product Made by Mature B Lymphocytes.
Anselm Ender, Alanna Short, Lisa Miosge, Hannes Bergmann, Yovina Sontani, Edward Bertram, Belinda Whittle, Bhavani Balakishnan, Kaoru Yoshida, Geoff Sjollema, Matthew A. Field, Daniel Andrews, Hiromi Hagiwara, and Christopher C. Goodnow
Proceedings of the National Academy of Sciences of the United States of America. Published online Doi/10.1073/pnas.1402739111 (2014)


Analyses of Aquaporin 9 in Human Epidermis and Cultured Keratinocytes.
Yoshinori Sugiyama, Kohei Yamazaki, Ayumi Kusak-Kikushima, Kyoko Nakahigashi, Hiromi Hagiwara, Yoshiki Miyachi, and Mariko Hara-Chikuma
FEBS Open Bio, 4, 611-616 (2014)


Effects of Fisetin on Mouse Lipid Metabolism in Vitro and in Vivo.
Tomoaki Yonesaka, Kaoru Yoshida, Shunsuke Iizuka, and Hiromi Hagiwara
The Journal of Functional Foods in Health and Disease, 4(10), 429-441 (2014)


2012年

Nephrotoxic Effect of Subchronic Exposure to S-(1, 2-Dichlorovinyl)-L-cyctein in Mice.
Nobuaki Shirai, Mareki Ohtsuji, Keitaro Hagiwara, Hiroki Tomisawa, Naomi Ohtsuji, Sachiko Hirose, and Hiromi Hagiwara
The Journal of Toxicological Sciences, 37(5), 871-878 (2012)


2011年

Olive Polyphenol, Hydroxytyrosol, Prevents Bone Loss.
Keitaro Hagiwara, Tadashi Goto, Masahiro Araki, Hitoshi Miyazaki, and Hiromi Hagiwara
European Journal of Pharmacology, 662, 78-84 (2011)


Iron Overload Inhibits Calcification and Differentiation of ATDC5 Cells.

Tomoya Ohno, Noriaki Hashimoto, Kanako Yamazaki, Ken-ichi Mitsui, Hiroyuki Nishimura, and Hiromi Hagiwara
Journal of Biochemistry, Oct 11. [Epub ahead of print] (2011)


2009年

Excess Iron Inhibits Osteoblast Metabolism.
Kanako Yamasaki and Hiromi Hagiwara
Toxicology Letters, 191, 211-215 (2009)


2008年

Effects of alkylphenols on bone metabolism in vivo and in vitro.
Hagiwara H, Sugizaki T, Tsukamoto Y, Senoh E, Goto T, Ishihara Y.
Toxicology Letters 181 (2008)13-18


2007年

A Novel Member of the Calcitonin Gene-related Peptide Family, Calcitonin Receptor-stimulating Peptide, Inhibits the Formation and Activity of Osteoclasts.
Michika Notoya, Rumiko Arai, Takeshi Katafuchi, Naoto Minamino, and Hiromi Hagiwara
Eur. J. Pharmacol., 560, 234-239 (2007)


2006年

Curcumin Inhibits the Proliferation and Mineralization of Cultured Osteoblasts.
Michitaka Notoya, Hiroyuki Nishimura, Je-Tae Woo, Kazuo Nagai, Yoko Ishihara, and Hiromi Hagiwara
Eur. J. Pharmacol., 534, 55-62 (2006)


Testicular Zinc Finger Protein Recruits Histone Deacetylase 2 and Suppresses the Transactivation Function and Intranuclear Foci Formation of Agonist-bound Androgen Receptor Competitively with TIF2.
Rong-Hua Tao, Hisaya Kawate, Yin Wu, Keizo Ohnaka, Masamichi Ishizuka, Atsuto Inoue, Hiromi Hagiwara, and Ryoichi Takayanagi
Mol. Cellular Endocrinol., 247 (1-2), 150-165 (2006)


Opposite Effects of Alternative TZF Spliced Variants on Androgen Receptor.
Rong-Hua Tao, Hisaya Kawate, Ohnaka Keizo, Masamichi Ishizuka, Hiromi Hagiwara, and Ryoichi Takayanagi
Biochem. Biophys. Res. Commun., 341 (2), 515-521 (2006)


2005年

Zinc Finger Protein TZF Is a Novel Corepressor of Androgen Receptor.
Masamichi Ishizuka, Hisaya Kawate, Ryoichi Takayanagi, Hirotaka Ohshima, Tao Rong-Hua and Hiromi Hagiwara
Biochem. Biophys. Res. Commun., 331, 1025-1031 (2005)


2004年

Runx-2 is not essential for the vitamin D-regulated expression of RANKL and osteoprotegerin in osteoblastic cells.
Notoya M, Otsuka E, Yamaguchi A, Hagiwara H.
Biochem Biophys Res Commun. 2004 Nov 12;324(2):655-60.


Inhibition of ossification in vivo and differentiation of osteoblasts in vitro by tributyltin.
Tsukamoto Y, Ishihara Y, Miyagawa-Tomita S, Hagiwara H.
Biochem Pharmacol. 2004 Aug 15;68(4):739-46.


Quercetin, a flavonoid, inhibits the proliferation, differentiation, and mineralization of osteoblasts in vitro.
Notoya M, Tsukamoto Y, Nishimura H, Woo JT, Nagai K, Lee IS, Hagiwara H.
Eur J Pharmacol. 2004 Feb 6;485(1-3):89-96.


Inhibition of osteoclast formation by 3-methylcholanthrene, a ligand for arylhydrocarbon receptor: suppression of osteoclast differentiation factor in osteogenic cells.
Naruse M, Otsuka E, Naruse M, Ishihara Y, Miyagawa-Tomita S, Hagiwara H.
Biochem Pharmacol. 2004 Jan 1;67(1):119-27.


共同研究
Quercetin suppresses bone resorption by inhibiting the differentiation and activation of osteoclasts.
Woo JT, Nakagawa H, Notoya M, Yonezawa T, Udagawa N, Lee IS, Ohnishi M, Hagiwara H, Nagai K.
Biol Pharm Bull. 2004 Apr;27(4):504-9.


2003年

Treatment of Myoblastic C2C12 Cells with BMP-2 Stimulates Vitamin D-induced Formation of Osteoclasts.
Otsuka E, Notoya M, Hagiwara H
Calcif Tissue Int 2003 Apr 8


Molecular cloning and characteristics of a novel zinc finger protein and its splice variant whose transcripts are expressed during spermatogenesis.
Ishizuka M, Ohshima H, Tamura N, Nakada T, Inoue A, Hirose S, Hagiwara H
Biochem Biophys Res Commun. 2003 Feb 21;301(4):1079-85.


Altered regulation of endothelin A receptor subtype in the cerebral arterioles in response to a Japanese-style diet, in stroke-prone hypertensive rats.
Rossi GP, Colonna S, Belloni AS, Savoia C, Albertin G, Nussdorfer GG, Hagiwara H, Rubattu S,Volpe M
J Hypertens 2003 Jan;21(1):105-113


Endothelin B receptors are expressed by astrocytes and regulate astrocyte hypertrophy in the normal and injured CNS.
Rogers SD, Peters CM, Pomonis JD, Hagiwara H, Ghilardi JR, Mantyh PW
Glia 2003 Jan 15;41(2):180-90


2002年

3-methylcholanthrene, which binds to the arylhydrocarbon receptor, inhibits proliferation and differentiation of osteoblasts in vitro and ossification in vivo.>
Naruse M, Ishihara Y, Miyagawa-Tomita S, Koyama A, Hagiwara H
Endocrinology, 143(9):3575-81(2002 Sep)


Identification of a Novel Osteoblastic Gene, Inducible by C-type Natriuretic Peptide, Whose Transcript Might Function in Mineralization as a Noncoding RNA.
Atsuto Inoue, Yuki Kobayashi, Masamichi Ishizuka, Shigehisa Hirose, Hiromi Hagiwara
Calcified Tissue International, 70(2), 111-116 (2002 Feb)


2001年

Reciprocal Control of Expression of mRNAs for Osteoclast Differentiation Factor and Osteoprotegerin in Osteogenic Stromal Cells by Genistein: Evidence for the Involvement of Topoisomerase II in Osteoclastogenesis.
Takumi Yamagishi, Eri Otsuka, Hiromi Hagiwara
Endocrinology, 142(8): 3632-3637 (2001 Aug)


2000年

Vasoactive peptide-regulated gene expression during osteoblastic differentiation.
Atsuto Inoue, Asako Kamiya, Atsushi Ishiji, Yoshiharu Hiruma, Shigehisa Hirose, Hiromi Hagiwara
J. Cardiovasc. Pharmacol., 36(5 Suppl 1): S286-9 (2000)


Role of ascorbic acid in the osteoclast formation: induction of osteoclast differentiation factor with formation of the extracellular collagen matrix.
Eri Otsuka, Yoshihisa Kato, Shigehisa Hirose, Hiromi Hagiwara
Endocrinology, 141: 3006-3011 (2000)


The Transcript for a Novel Protein with a Zinc Finger Motif Is Expressed as Specific Stages of Mouse Spermatogenesis.
Atsuto Inoue, Atsushi Ishiji, Satoshi Kasagi, Masamichi Ishizuka, Shigehisa Hirose, Tadashi Baba, Hiromi Hagiwara
Biochem. Biophys. Res. Commun., 273: 398-403 (2000)


Nitric oxide accerlerates the ascorbic acid-induced osteoblastic differentiation of mouse stromal ST2 cells by stimulating the production of prostaglandin E2.
Atsushi Koyama, Eri Otsuka, Atsuto Inoue, Shigehisa Hirose, Hiromi Hagiwara
Eur. J. Pharmacol., 391: 225-231 (2000)


Condensation of mRNA for the Natriuretic Peptide Receptor-C in Hypertrophic Chondrocytes of the Fetal Mouse Tibia.
Yasuji Yamashita, Kazuhiko Takeshige, Atsuto Inoue, Ako Takamori, Shigehisa Hirose, Hiromi Hagiwara
J. Biochem., 127: 177-179 (2000)


1999年

Effects of nicotine on cultured cells suggest that it can influence the formation and resorption of bone.
Sachiko Yuhara, Satoshi Kasagi, Atsuto Inoue, Eri Otsuka, Shigehisa Hirose, Hiromi Hagiwara
Eur. J. Pharmacol., 383: 387-393 (1999)


Characterization of osteoblastic differentiation of stromal cell line ST2 that is induced by ascorbic acid.
Eri Otsuka, Akira Yamaguchi, Shigehisa Hirose, Hiromi Hagiwara
Am. J. Physiol., 277: C132-C138 (1999)


Ipriflavone down-regulates endothelin receptor levels during differentiation of rat calvarial osteoblast-like cells.
Hiromi Hagiwara, Mitsuhide Naruse, Chika Adachi, Atsuto Inoue, Yoshiharu Hiruma, Eri Otsuka, Kiyoko Naruse, Hiroshi Demura, and Shigehisa Hirose
J. Biochem., 126: 168-173 (1999)


Correlation between incuction of expression of biglycan and mineralization by C-type natriuretic peptide in osteoblastic cells.
Atsuto Inoue, Tomoko Hayakawa, Eri Otsuka, Asako Kamiya, Yoshirou Suzuki, Shigehisa Hirose, Hiromi Hagiwara
J. Biochem., 125: 103-108 (1999)


1998年

Endothelins inhibit the mineralization of osteoblastic MC3T3-E1 cells through the A-type endothelin receptor.
Yoshiharu Hiruma, Atsuto Inoue, Aiko Shiohama, Eri Otsuka, Shigehisa Hirose, Akira Yamaguchi, Hiromi Hagiwara
Am. J. Physiol., 275: R1099-R1105 (1998)


Effects of nitric oxide from exogenous nitric oxde donors on osteoblastic metabolism.
Eri Otsuka, Kiyoko Hirano, Shouji Matsushita, Atsuto Inoue, Shigehisa Hirose, Akira Yamaguchi, Hiromi Hagiwara
Eur. J. Pharmacol., 349: 345-350 (1998)


Endothelins inhibit mineralization of rat calvarial osteoblast-like cells.
Yoshiharu Hiruma, Atsuto Inoue, Aiko Shiohama, Eri Otsuka, Shigehisa Hirose, Akira Yamaguchi, Hiromi Hagiwara
J. Cardiovasc. Pharmacol., 31(Suppl. 1): S521-523 (1998)


Deceleration by angiotensin II of the differentiation and bone formation of rat calvarial osteoblastic cells.
Hiromi Hagiwara, Yoshiharu Hiruma, Atsuto Inoue, Akira Yamaguchi, Shigehisa Hirose
J. Endocrinol., 156: 543-550 (1998)


1997年

Angiotensin II stimulates the proliferation of osteoblast-rich populations of cells from rat calvariae.
Yoshiharu Hiruma, Atsuto Inoue, Shigehisa Hirose, Hiromi Hagiwara
Biochem. Biophys. Res. Cpmmun., 230: 176-178 (1997)


1996年

Stimulation by retinoids of the natriuretic peptide system of osteoblastic MC3T3-E1 cells.
Atsuto Inoue, Eri Otsuka, Yoshiharu Hiruma, Shigehisa Hirose, Mayumi Furuya, Shoji Tanaka, Hiromi Hagiwara
Biochem. Biophys. Res. Cpmmun., 228: 182-186 (1996 Nov 1)


Inhibition of proliferation of chondrocytes by specific receptors in response to retinoids.
Hiromi Hagiwara, Atsuto Inoue, Shigeo Nakajo, Kazuyasu Nakaya, Soichi Kojima, Shigehisa Hirose
Biochem. Biophys. Res. Commun., 222(2): 220-4 (1996 May 15)


cGMP produced in response to ANP and CNP regulates proliferation and differentiation osteoblastic cells.
Hiromi Hagiwara, Atsuto Inoue, Akira Yamaguchi, Satoshi Yokose, Mayumi Furuya, Shoji Tanaka, Shigehisa Hirose
Am. J. Physiol., 270(5 pt 1): C1311-C1318 (1996 May)


Stimulation by C-type natriuretic peptide of the differentiation of clonal osteoblastic MC3T3-E1 cells.
Atsuto Inoue, Yoshiharu Hiruma, Shigehisa Hirose, Akira Yamaguchi, Mayumi Furuya, Shoji Tanaka, Hiromi Hagiwara
Biochem. Biophys. Res. Cpmmun., 221(3): 703-707 (1996 Apr 25)


Change in the expression of C-type natriuretic peptide and its receptor, B-type natriuretic peptide receptor, during dedifferentiation of chondrocytes into fibroblast-like cells.
Hiromi Hagiwara, Atsuto Inoue, Mayumi Furuya, Shoji Tanaka, Shigehisa Hirose
J. Biochem., 119(2): 264-267 (1996 Feb)


1995年

Reciprocal regulation by cyclic nucleotides of the differentiation of rat osteoblast-like cells and mineralization of nodules.
Atsuto Inoue, Yoshiharu Hiruma, Shigehisa Hirose, Akira Yamaguchi, and Hiromi Hagiwara
Biochem. Biophys. Res. Commun., 215(3): 1104-1110 (1995 Oct 24)