発表論文
2021年
miR-34a-5p might have an important role for inducing apoptosis by down-regulation of SNAI1 in apigenin-treated lung cancer cells.
Rieko Aida, Keitaro Hagiwara, Kazunori Okano, Kyoko Nakata, Yuho Obata, Takahiro Yamashita, Kaoru Yoshida, Hiromi Hagiwara
Mol Biol Rep. 2021 Mar 6. doi: 10.1007/s11033-021-06255-7.
2020年
Effects of soybean isoflavone genistein and daidzein on proliferation and viability of human osteogenic sarcoma cell Saos-2.
H Wakou, K Nakata, H Hagiwara
Bone Reports 13, 100420
Localization of the Trichloroethylene-related Compound S-(1, 2-Dichlorovinyl)-L-Cysteine in Mouse Cartilage.
Norikazu Komoriya, Nobuaki Shirai, Hiroki Tomisawa and Hiromi Hagiwara
Fundamental Toxicological Sciences, 6 (7), 249-252 (2019)
2019年
4-Hydroxyderricin inhibits osteoclast formation and accelerates osteoblast differentiation.
Hagiwara H, Nakata K, Miyazaki H, Maehashi S, Komiyama Y, Aida R, Yoshida S, Kokubu D, Hagiwara K, Yoshida K.
Cytotechnology. 2019 Feb;71(1):15-22.
2016年
Abnormal Spermatogenesis and Male Infertility in Testicular Zinc Finger Protein ZFP318-knockout Mouse.
Masamichi Ishizuka, Eri Ohtsuka, Atsuto Inoue, Mirei Odaka, Hirotaka Ohshima, Norihisa Tamura, Kaoru Yoshida, Norihisa Sako, Katsutosi Sasaki, Tadashi Baba, Shin-ichi Kashiwabara, Masaru Okabe, Jyunko Noguchi, and Hiromi Hagiwara
Development Growth & Differentiation, 58, 600-608 (2016)
2015年
Carnosic Acid Inhibits the Formation of Osteoclasts through Attenuation of Expression of RANKL.
Hiromi Hagiwara, Roshan Basnet, Sundari I. Wiyasihati, Kyoko Nakata, Keitaro Hagiwara,Hitoshi Miyazaki, and Kaoru Yoshida
PharmaNutriton, 3(1), 1-6 (2015) Doi: 10.1016/j.phanu.2014.11.003
Apigenin Inhibits Osteoblastogenesis and Osteoclastogenesis and Prevents Bone Loss in Ovariectomized Mice.
Tadashi Goto, Keitaro Hagiwara, Nobuyuki Shirai, Kaoru Yoshida, and Hiromi Hagiwara
TCytotechnology, Published online Doi/10.1007/s10616-014-9694-3 (2014)
2014年
Zinc-finger Protein ZFP318 Is Essential for Expression of IgD, the Alternatively Spliced Igh Product Made by Mature B Lymphocytes.
Anselm Ender, Alanna Short, Lisa Miosge, Hannes Bergmann, Yovina Sontani, Edward Bertram, Belinda
Whittle, Bhavani Balakishnan, Kaoru Yoshida, Geoff Sjollema, Matthew A. Field, Daniel Andrews,
Hiromi Hagiwara, and Christopher C. Goodnow
Proceedings of the National Academy of Sciences of the United States of America. Published online
Doi/10.1073/pnas.1402739111 (2014)
Analyses of Aquaporin 9 in Human Epidermis and Cultured Keratinocytes.
Yoshinori Sugiyama, Kohei Yamazaki, Ayumi Kusak-Kikushima, Kyoko Nakahigashi,
Hiromi Hagiwara, Yoshiki Miyachi, and Mariko Hara-Chikuma
FEBS Open Bio, 4, 611-616 (2014)
Effects of Fisetin on Mouse Lipid Metabolism in Vitro and in Vivo.
Tomoaki Yonesaka, Kaoru Yoshida, Shunsuke Iizuka, and Hiromi Hagiwara
The Journal of Functional Foods in Health and Disease, 4(10), 429-441 (2014)
2012年
Nephrotoxic Effect of Subchronic Exposure to S-(1, 2-Dichlorovinyl)-L-cyctein in Mice.
Nobuaki Shirai, Mareki Ohtsuji, Keitaro Hagiwara, Hiroki Tomisawa, Naomi Ohtsuji, Sachiko Hirose, and Hiromi Hagiwara
The Journal of Toxicological Sciences, 37(5), 871-878 (2012)
2011年
Olive Polyphenol, Hydroxytyrosol, Prevents Bone Loss.
Keitaro Hagiwara, Tadashi Goto, Masahiro Araki, Hitoshi Miyazaki, and Hiromi Hagiwara
European Journal of Pharmacology, 662, 78-84 (2011)
Iron Overload Inhibits Calcification and Differentiation of ATDC5 Cells.
Tomoya Ohno, Noriaki Hashimoto, Kanako Yamazaki, Ken-ichi Mitsui, Hiroyuki Nishimura, and Hiromi Hagiwara
Journal of Biochemistry, Oct 11. [Epub ahead of print] (2011)
2009年
Excess Iron Inhibits Osteoblast Metabolism.
Kanako Yamasaki and Hiromi Hagiwara
Toxicology Letters, 191, 211-215 (2009)
2008年
Effects of alkylphenols on bone metabolism in vivo and in vitro.
Hagiwara H, Sugizaki T, Tsukamoto Y, Senoh E, Goto T, Ishihara Y.
Toxicology Letters 181 (2008)13-18
2007年
A Novel Member of the Calcitonin Gene-related Peptide Family, Calcitonin Receptor-stimulating Peptide, Inhibits the Formation and Activity of Osteoclasts.
Michika Notoya, Rumiko Arai, Takeshi Katafuchi, Naoto Minamino, and Hiromi Hagiwara
Eur. J. Pharmacol., 560, 234-239 (2007)
2006年
Curcumin Inhibits the Proliferation and Mineralization of Cultured Osteoblasts.
Michitaka Notoya, Hiroyuki Nishimura, Je-Tae Woo, Kazuo Nagai, Yoko Ishihara, and Hiromi Hagiwara
Eur. J. Pharmacol., 534, 55-62 (2006)
Testicular Zinc Finger Protein Recruits Histone Deacetylase 2 and Suppresses the Transactivation Function and Intranuclear Foci Formation of Agonist-bound Androgen Receptor Competitively with TIF2.
Rong-Hua Tao, Hisaya Kawate, Yin Wu, Keizo Ohnaka, Masamichi Ishizuka, Atsuto Inoue, Hiromi Hagiwara, and Ryoichi Takayanagi
Mol. Cellular Endocrinol., 247 (1-2), 150-165 (2006)
Opposite Effects of Alternative TZF Spliced Variants on Androgen Receptor.
Rong-Hua Tao, Hisaya Kawate, Ohnaka Keizo, Masamichi Ishizuka, Hiromi Hagiwara, and Ryoichi Takayanagi
Biochem. Biophys. Res. Commun., 341 (2), 515-521 (2006)
2005年
Zinc Finger Protein TZF Is a Novel Corepressor of Androgen Receptor.
Masamichi Ishizuka, Hisaya Kawate, Ryoichi Takayanagi, Hirotaka Ohshima, Tao Rong-Hua and Hiromi Hagiwara
Biochem. Biophys. Res. Commun., 331, 1025-1031 (2005)
2004年
Runx-2 is not essential for the vitamin D-regulated expression
of RANKL and osteoprotegerin in osteoblastic cells.
Notoya M, Otsuka E, Yamaguchi A, Hagiwara H.
Biochem Biophys Res Commun. 2004 Nov 12;324(2):655-60.
Inhibition of ossification in vivo and differentiation of osteoblasts in vitro
by tributyltin.
Tsukamoto Y, Ishihara Y, Miyagawa-Tomita S, Hagiwara H.
Biochem Pharmacol. 2004 Aug 15;68(4):739-46.
Quercetin, a flavonoid, inhibits the proliferation, differentiation, and
mineralization of osteoblasts in vitro.
Notoya M, Tsukamoto Y, Nishimura H, Woo JT, Nagai K, Lee IS, Hagiwara H.
Eur J Pharmacol. 2004
Feb 6;485(1-3):89-96.
Inhibition of osteoclast formation by 3-methylcholanthrene, a ligand for
arylhydrocarbon receptor: suppression of osteoclast differentiation factor
in osteogenic cells.
Naruse M, Otsuka E, Naruse M, Ishihara Y, Miyagawa-Tomita S, Hagiwara H.
Biochem Pharmacol. 2004 Jan 1;67(1):119-27.
共同研究
Quercetin suppresses bone resorption by inhibiting the differentiation
and activation of osteoclasts.
Woo JT, Nakagawa H, Notoya M, Yonezawa T, Udagawa N, Lee IS, Ohnishi M, Hagiwara H, Nagai K.
Biol Pharm Bull. 2004
Apr;27(4):504-9.
2003年
Molecular cloning and characteristics of a novel zinc finger protein and its splice variant whose transcripts are expressed during spermatogenesis.
Ishizuka M, Ohshima H, Tamura N, Nakada T, Inoue A, Hirose S, Hagiwara H
Biochem Biophys Res Commun. 2003 Feb 21;301(4):1079-85.
Altered regulation of endothelin A receptor subtype in the
cerebral arterioles in response to a Japanese-style diet, in stroke-prone
hypertensive rats.
Rossi GP, Colonna S, Belloni AS, Savoia C, Albertin G, Nussdorfer GG, Hagiwara H, Rubattu S,Volpe M
J Hypertens 2003 Jan;21(1):105-113
Endothelin B receptors are expressed by astrocytes and regulate astrocyte hypertrophy in the normal and injured CNS.
Rogers SD, Peters CM, Pomonis JD, Hagiwara H, Ghilardi JR, Mantyh PW
Glia 2003 Jan 15;41(2):180-90
2002年
3-methylcholanthrene, which binds to the arylhydrocarbon receptor, inhibits
proliferation and differentiation of osteoblasts in vitro and ossification in vivo.>
Naruse M, Ishihara Y, Miyagawa-Tomita S, Koyama A, Hagiwara H
Endocrinology, 143(9):3575-81(2002 Sep)
Identification of a Novel Osteoblastic Gene, Inducible by C-type Natriuretic Peptide, Whose Transcript Might Function in Mineralization as a
Noncoding RNA.
Atsuto Inoue, Yuki Kobayashi, Masamichi Ishizuka,
Shigehisa Hirose, Hiromi Hagiwara
Calcified Tissue International,
70(2), 111-116 (2002 Feb)
2001年
Reciprocal Control of Expression of mRNAs for Osteoclast
Differentiation Factor and Osteoprotegerin in Osteogenic Stromal Cells by
Genistein: Evidence for the Involvement of Topoisomerase II in
Osteoclastogenesis.
Takumi Yamagishi, Eri Otsuka, Hiromi
Hagiwara
Endocrinology, 142(8): 3632-3637 (2001 Aug)
2000年
Vasoactive peptide-regulated gene expression during osteoblastic
differentiation.
Atsuto Inoue, Asako Kamiya, Atsushi Ishiji,
Yoshiharu Hiruma, Shigehisa Hirose, Hiromi Hagiwara
J. Cardiovasc.
Pharmacol., 36(5 Suppl 1): S286-9 (2000)
Role of ascorbic acid in the osteoclast formation: induction of
osteoclast differentiation factor with formation of the extracellular collagen
matrix.
Eri Otsuka, Yoshihisa Kato, Shigehisa Hirose, Hiromi Hagiwara
Endocrinology, 141: 3006-3011 (2000)
The Transcript for a Novel Protein with a Zinc Finger Motif Is
Expressed as Specific Stages of Mouse Spermatogenesis.
Atsuto Inoue,
Atsushi Ishiji, Satoshi Kasagi, Masamichi Ishizuka, Shigehisa Hirose, Tadashi
Baba, Hiromi Hagiwara
Biochem. Biophys. Res. Commun., 273:
398-403 (2000)
Nitric oxide accerlerates the ascorbic acid-induced osteoblastic
differentiation of mouse stromal ST2 cells by stimulating the production of
prostaglandin E2.
Atsushi Koyama, Eri Otsuka, Atsuto Inoue, Shigehisa
Hirose, Hiromi Hagiwara
Eur. J. Pharmacol., 391: 225-231
(2000)
Condensation of mRNA for the Natriuretic Peptide Receptor-C in
Hypertrophic Chondrocytes of the Fetal Mouse Tibia.
Yasuji Yamashita,
Kazuhiko Takeshige, Atsuto Inoue, Ako Takamori, Shigehisa Hirose, Hiromi Hagiwara
J. Biochem., 127: 177-179 (2000)
1999年
Effects of nicotine on cultured cells suggest that it can
influence the formation and resorption of bone.
Sachiko Yuhara,
Satoshi Kasagi, Atsuto Inoue, Eri Otsuka, Shigehisa Hirose, Hiromi Hagiwara
Eur. J. Pharmacol., 383: 387-393 (1999)
Characterization of osteoblastic differentiation of stromal cell
line ST2 that is induced by ascorbic acid.
Eri Otsuka, Akira
Yamaguchi, Shigehisa Hirose, Hiromi Hagiwara
Am. J. Physiol.,
277: C132-C138 (1999)
Ipriflavone down-regulates endothelin receptor levels during
differentiation of rat calvarial osteoblast-like cells.
Hiromi Hagiwara, Mitsuhide Naruse, Chika Adachi, Atsuto Inoue, Yoshiharu Hiruma, Eri
Otsuka, Kiyoko Naruse, Hiroshi Demura, and Shigehisa Hirose
J. Biochem., 126: 168-173 (1999)
Correlation between incuction of expression of biglycan and
mineralization by C-type natriuretic peptide in osteoblastic
cells.
Atsuto Inoue, Tomoko Hayakawa, Eri Otsuka, Asako Kamiya,
Yoshirou Suzuki, Shigehisa Hirose, Hiromi Hagiwara
J. Biochem.,
125: 103-108 (1999)
1998年
Endothelins inhibit the mineralization of osteoblastic MC3T3-E1
cells through the A-type endothelin receptor.
Yoshiharu Hiruma,
Atsuto Inoue, Aiko Shiohama, Eri Otsuka, Shigehisa Hirose, Akira Yamaguchi, Hiromi Hagiwara
Am. J. Physiol., 275: R1099-R1105 (1998)
Effects of nitric oxide from exogenous nitric oxde donors on
osteoblastic metabolism.
Eri Otsuka, Kiyoko Hirano, Shouji
Matsushita, Atsuto Inoue, Shigehisa Hirose, Akira Yamaguchi, Hiromi Hagiwara
Eur. J. Pharmacol., 349: 345-350 (1998)
Endothelins inhibit mineralization of rat calvarial
osteoblast-like cells.
Yoshiharu Hiruma, Atsuto Inoue, Aiko Shiohama,
Eri Otsuka, Shigehisa Hirose, Akira Yamaguchi, Hiromi Hagiwara
J. Cardiovasc. Pharmacol., 31(Suppl. 1): S521-523 (1998)
Deceleration by angiotensin II of the differentiation and bone
formation of rat calvarial osteoblastic cells.
Hiromi Hagiwara,
Yoshiharu Hiruma, Atsuto Inoue, Akira Yamaguchi, Shigehisa Hirose
J. Endocrinol., 156: 543-550 (1998)
1997年
Angiotensin II stimulates the proliferation of osteoblast-rich
populations of cells from rat calvariae.
Yoshiharu Hiruma, Atsuto
Inoue, Shigehisa Hirose, Hiromi Hagiwara
Biochem. Biophys. Res. Cpmmun., 230: 176-178 (1997)
1996年
Stimulation by retinoids of the natriuretic peptide system of
osteoblastic MC3T3-E1 cells.
Atsuto Inoue, Eri Otsuka, Yoshiharu
Hiruma, Shigehisa Hirose, Mayumi Furuya, Shoji Tanaka, Hiromi Hagiwara
Biochem. Biophys. Res. Cpmmun., 228: 182-186 (1996 Nov 1)
Inhibition of proliferation of chondrocytes by specific receptors
in response to retinoids.
Hiromi Hagiwara, Atsuto Inoue, Shigeo
Nakajo, Kazuyasu Nakaya, Soichi Kojima, Shigehisa Hirose
Biochem. Biophys.
Res. Commun., 222(2): 220-4 (1996 May 15)
cGMP produced in response to ANP and CNP regulates proliferation
and differentiation osteoblastic cells.
Hiromi Hagiwara, Atsuto
Inoue, Akira Yamaguchi, Satoshi Yokose, Mayumi Furuya, Shoji Tanaka, Shigehisa
Hirose
Am. J. Physiol., 270(5 pt 1): C1311-C1318 (1996 May)
Stimulation by C-type natriuretic peptide of the differentiation
of clonal osteoblastic MC3T3-E1 cells.
Atsuto Inoue, Yoshiharu
Hiruma, Shigehisa Hirose, Akira Yamaguchi, Mayumi Furuya, Shoji Tanaka, Hiromi Hagiwara
Biochem. Biophys. Res. Cpmmun., 221(3): 703-707 (1996 Apr 25)
Change in the expression of C-type natriuretic peptide and its
receptor, B-type natriuretic peptide receptor, during dedifferentiation of
chondrocytes into fibroblast-like cells.
Hiromi Hagiwara, Atsuto
Inoue, Mayumi Furuya, Shoji Tanaka, Shigehisa Hirose
J. Biochem.,
119(2): 264-267 (1996 Feb)
1995年
Reciprocal regulation by cyclic nucleotides of the differentiation
of rat osteoblast-like cells and mineralization of nodules.
Atsuto Inoue, Yoshiharu Hiruma, Shigehisa Hirose, Akira Yamaguchi, and Hiromi Hagiwara
Biochem. Biophys. Res. Commun., 215(3): 1104-1110 (1995 Oct 24)